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Therapeutic strategies in acute middle cerebral artery occlusion: ultrasound enhanced intravenous t-PA versus additional endovascular treatment: a comparison of two centers

Therapeutic strategies in acute middle cerebral artery occlusion: ultrasound enhanced intravenous t-PA versus additional endovascular treatment: a comparison of two centers

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00005305
Enrollment
80
Registered
2013-09-13
Start date
2013-09-18
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I63

Interventions

Group 1: Retrospective analysis of patients with a combined approach with intravenous thrombolysis with rtPA and mechanical thrombectomy Group 2: Retrospective analysis of patients with intravenous t

Sponsors

Neurologische KlinikUniversitätsklinikum Freiburg
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients treated in the period between 01.07.2007 and 30.6.2013 in the respective hospitals who are >=18 yrs and received intravenous thrombolysis because of MCA occlusion and 2. in center A additionally intraarterial intervention, in center B additionally sonothrombolysis.

Exclusion criteria

Exclusion criteria: Patients with missing information about duration and type of sonothrombolysis

Design outcomes

Primary

MeasureTime frame
Comparison of patients in both centers regarding early NIH improvement (delta NIH-SS and absolute NIH-SS at 24 h) and degree of disability (modified Rankin Scale, Barthel Index) at hospital discharge and at discharge from the rehabilitation clinic.

Secondary

MeasureTime frame
Comparison of both therapeutic strategies regarding: - Effect of clinical factors (age, sex, vascular risk factors, blood glucose etc.) on clinical outcome - rate of symptomatic intracerebral hemorrhage - other adverse events (angioedema, complications during angiography) for both therapeutic strategies - size of infarction - number of patients with early recanalization

Countries

Germany

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026