G35
Conditions
Interventions
Group 1: transcranial direct current stimulation (tDCS)
current strength 2 mA
duration 20 min
total 3 sessions
anode dorsolateral prefrontal cortex left
cathode supraorbital right.
Group 2: sham stimulation
current strength 0 mA
other parameters as arm 1.
Group 3: transcranial random noise stimulation (tRNS)
offset 1 mA
frequency 0-640 Hz
other parameters as in arm 1.
Sponsors
Association ANTALGOCentre Hospitalier Nemours
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: multiple sclerosis; all subtypes; patients with and without pain
Exclusion criteria
Exclusion criteria: other neurologic disorders, severe internal disorders, lack of informed consent, metal implants, seizures in medical history
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Completion of the study after 9 weeks: (I) significant improvement of attention, proven by a lower failure rate in the attention network test and (II) significant attenuation of pain related evoked potentials in the EEG after active tDCS and tRNS compared to sham stimulation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Completion of the study after 9 weeks: (I) Significant improvement of depression rating in the Hospital Anxiety ans Depression Scale (HADS) and the Modified Fatigue Impact Scale (MFIS) and (II) significant reduction in pain perception in the Brief Pain Inventory (BPI) after active tDCS and tRNS compared to sham stimulation. | — |
Countries
France
Contacts
Public ContactSamar Ayache
Service de Physiologie, Explorations fonctionelles, EA 4391, Hôpital Henri Mondor
Outcome results
None listed