A pharmacological provocation of the glutamatergic and the cholinergic system. A fMRI study.

A pharmacological provocation of the glutamatergic and the cholinergic system. A fMRI study. - NEWMDES pharmaco fmri

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00005268

Enrollment

Registered

2013-09-12

Start date

2013-09-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteers

Interventions

Group 1: 40 min ketamine infusion 0.5 mg /kg body weight Group 2: 0.4 µg scopolamine infusion per kg bodyweight for 15 min Group 3: waterinfusion 40 min (placebo)

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: healthy volunteers

Exclusion criteria

Exclusion criteria: pregnany, psychiatric or neurologic disease, contraindications for scopolamine or ketamine, glaucoma, tachyarrhythmia, ileus, myasthenia gravis, hyperthyreosis, renal insufficiency, liver function disorder, history of heart disease

Design outcomes

Primary

Measure	Time frame
fmri BOLD response one hour after infusion	—

Countries

Germany

Contacts

Public ContactOliver Grimm

ZI Mannheim

oliver.grimm@zi-mannheim.de0621 1703 6341

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026