Modulation of the brain through directed challenge of the ascending reticular actiovationsystem (ARAS) or of the dopaminergic system through measurement of a standardized fMRI battery in healthy volunteers

Modulation of the brain through directed challenge of the ascending reticular actiovationsystem (ARAS) or of the dopaminergic system through measurement of a standardized fMRI battery in healthy volunteers - NEWMEDS pharmaco fmri II

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00005267

Enrollment

Registered

2013-09-23

Start date

2014-02-10

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy Volunteers

Interventions

Group 1: group A one time oral intake 3mg haloperidol Group 2: group A one time intake 7.5 mg olanzapine Group 3: group A placebo Group 4: group B one time intake 200mg modafinil Group 5: group B one

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. Healthy subjects, 18 to 40 years of age, inclusive. Healthy status is defined by absence of evidence of any active or chronic disease following a detailed medical and surgical history, a complete physical examination including vital signs, 12-lead ECG, hematology, blood chemistry, serology and urinalysis. 2. A BMI between 22.0 to 30.0 kg/m2 inclusive. 3. Able to participate and willing to give written informed consent and to comply with the study restrictions.

Exclusion criteria

Exclusion criteria: Any somatic or mental illness, especially those that might interfere with medication.

Design outcomes

Primary

Measure	Time frame
BOLD response in a standardized fmri test battery (Plichta et al. 2012)	—

Secondary

Measure	Time frame
Neuropsychological tests( CANTAB: Cambridge neuropsychological assement)	—

Countries

Germany

Contacts

Public ContactOliver Grimm

ZI Mannheim

oliver.grimm@zi-mannheim.de0621 1703 6341

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026