L29.9
Conditions
Interventions
Group 1: All 160 patients: induction of itch with cowhage, histamine or capsaicin. Before the start of the investigation, subjects are tested for their skin nerve sensitivity with a QST test battery (
Sponsors
IZKF der medizinischen Fakultät der Universität Münster
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: chronic pruritus in atopic dermatitis (AD; sub-acute, chronic) OR brachioradial pruritus (BRP) OR prurigo nodularis (PN) controls (no atopic disposition, no dermatoses)
Exclusion criteria
Exclusion criteria: 1. only control subjects: History taking on atopic disposition (us-ing Erlangener atopy criteria), presence of pruritus 2. skin lesions in the area to be investigated (e.g. erosions, infections, acute exacerbation, cutaneous infections in atopic dermatitis), 3. neurological and psychiatric diseases in the patient history or currently suffering from the disease 4. skin type > III (mediterranean, dark and black skin type), 5. allergy to substances used /ingredients of the cream, 6. disorders preventing participation in the investigation, 7. intake of a drug, which influences the pruritus perception within the 2 weeks before examination 8. use of urea, polidocanol, menthol, capsaicin, topical steroids, topical keratolytics, exfoliators, self-tanning, topical or systemic antihistamines, naltrexon, anticonvulsants, sedatives within the 2 weeks before examination 9. systemic steroids, UV-therapy within the 4 weeks before examination 10. topical or systemic immunomodulators, antidepressants, anti-migraine medications within the 2 months before examination 11. NSAIDs and other analgesics 7 days before examination, 12. drug consumption, medication abuse, 13. cosmetic and skin care products in the area to be investigated on the day of examination, 14. participation in another investi-gation within the past 4 weeks 15. pregnancy, nursing mother
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| difference of cowhage-induced itch intensity on VAS in CP entities in comparison to controls | — |
Secondary
| Measure | Time frame |
|---|---|
| (a) difference in itch intensity on VAS between cowhage-induced and histamine and capsaicin-induced pruritus; (b) difference in itch intensity on VAS between cowhage-induced and NaCl-induced(control) pruritus; (c) difference in itch intensity on NRS between cowhage, histamine, capsaicin and NaCl-induced pruritus; (d) difference in cowhage-induced erythema flare reactions in comparison to those induced by histamine, capsaicin and NaCl in different CP entities and healthy volunteers; (e) differences in the expression of the receptors (TRPV1, Histamine 1 receptor (H1), Proteinase- 2 receptor (PAR2)), epidermal nerve fibers densities, pro-inflammatory mediators (IL-6, IL-8, TNF-alpha, NGF) in different CP entities compared to healthy controls, (f) difference in itch intensity on VAS between cowhage-induced itch and cowhage-induced itch in pretreated skin (pretreatment for 30 min with polidocanol and urea) in CP entities (AD, PN, CP) in comparison to healthy controls; (g) difference in endogenous inhibition of pain and itch obtained by DNIC/DPIC in CP entities in comparison to healthy volunteers | — |
Countries
Germany
Contacts
Public ContactSabine Stoll
Kompetenzzentrum chronischer Pruritus (KCP)
Outcome results
None listed