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Clinical outcomes following regenerative therapy of non-contained intrabony defects using a deproteinized bovine bone mineral combined with either enamel matrix derivative or collagen membrane. A randomized controlled clinical trial.

Clinical outcomes following regenerative therapy of non-contained intrabony defects using a deproteinized bovine bone mineral combined with either enamel matrix derivative or collagen membrane. A randomized controlled clinical trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00005214
Enrollment
40
Registered
2013-08-08
Start date
2011-02-08
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intrabony defects K05.3

Interventions

Group 1: Regeneration of non-contained intrabony defects with EMD (enamel matrix derivative) and DBBM (deproteinized bovine bone mineral). Through this surgical procedure, the intraosseous part of th

Sponsors

University of Naples "Federico II"
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Chronic periodontitis FMPS = 20 % at baseline FMBS = 20 % at baseline Non-contained osseous defect with an intrabony component = 3 mm located in the interproximal area of single-rooted teeth including first maxillary premolars and flat surfaces of molar teeth Presence of = 2 mm of keratinized tissue

Exclusion criteria

Exclusion criteria: Relevant medical conditions contraindicating surgical interventions Pregnancy or lactation Tobacco smoking Interproximal intrabony defects extending into the furcation area of molar teeth Untreated periodontal conditions

Design outcomes

Primary

MeasureTime frame
Gain in clinical attachment level measured with a graduated probe in mm at tooth sites with non-contained intrabony defects at baseline and after 12 months.

Secondary

MeasureTime frame
Residual probing pocket depth (PPD) in mm at tooth sites with non-contained intrabony defects after 12 months.

Countries

Italy

Contacts

Public ContactGiovanni E. Salvi

University of Bern

giovanni.salvi@zmk.unibe.ch+41(0)316323551

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026