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Identifying risk factors for dental erosion - is salivary enzyme activity a biomarker?

Identifying risk factors for dental erosion - is salivary enzyme activity a biomarker? - EASY1

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00005191
Enrollment
150
Registered
2013-08-06
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K03.2

Interventions

Group 1: Analysis of various salivary parameters in resting saliva and stimulated saliva in persons with erosion of different etiology (parameters: enzymatic activity, flow rate, pH, buffering capacit

Sponsors

Medizinische Zentrum für Zahn-, Mund- und Kieferheilkunde Poliklinik für Zahnerhaltungskunde und Präventive Zahnheilkunde
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: age of consent; informed written consent; Groups suffering from erosion: BEWE score of at least 2 in at least two sextants

Exclusion criteria

Exclusion criteria: cavitated carious lesions; insufficient fillings reaching the dentine; deep and inflamed periodontal pockets (= 4 mm with bleeding); other serious inflammatory processes in the oral cavity; allergy against the used dental materials

Design outcomes

Primary

MeasureTime frame
Activity of oral proteolytic enzymes (pepsin, trypsin, salivary collagenases, general proteolytic activity); correlation of activity with type of acid and with occurence of erosion—

Countries

Germany, Norway

Contacts

Public ContactNadine Schlüter

Medizinische Zentrum für Zahn-, Mund- und Kieferheilkunde Poliklinik für Zahnerhaltungskunde und Präventive Zahnheilkunde

nadine.schlueter@dentist.med.uni-giessen.de0641-99-46180

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026