Improvement of endogenous regeneration in female healthy volunteers through physical exercise “REBIRTH aktiv women”

Improvement of endogenous regeneration in female healthy volunteers through physical exercise “REBIRTH aktiv women” - Rebirth women

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00005159

Enrollment

313

Registered

2013-09-25

Start date

2013-11-20

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy female volunteers

Interventions

Group 1: Training intervention of 210 min per week over a period of 6 months. Training could be bicycling, ergometer training, swimming, walking, nordic-walking, jogging, running, rowing-ergometer, sh

Eligibility

Sex/Gender

Female

Age

45 Years to 65 Years

Inclusion criteria

Inclusion criteria: Females (45 - 65 years old) with a mainly sedentary way of work and no physical activity during leisure time.

Exclusion criteria

Exclusion criteria: - smoker -diabetes mellitus - operations during the last 8 weeks - artificial joint replacement less then 6 months before the start of the study - coronary/arterial disease - not medicamentous adequately treated hypertension - cancer - other diseases that interfere with physical activity.

Design outcomes

Primary

Measure	Time frame
Differences in telomere length in mononuclear cells (cells will be drwan from venous blood) between baseline and after 6 months intervention. Peak oxygen consumption (VO2peak) at baseline and after 6 months.	—

Secondary

Measure	Time frame
Measurements from venous blood: Oxidative stress (malondialdehyd, nitrate, nirtite), OxLDL, sodium, potassium, calcium, magnesium, phosphate, glucose, bilirubin, creatinine (eGFR), urea, urea acid, cholesterol, LDL cholesterol, HDL cholesterol, triglyceride, creatinkinase, Gamma-GT, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, ferritin, hs CRP, cystatine C, transferrinrezeptor, TSH, NTproBNP, LH, FSH, estradiol, progesterone, ex vivo stimulationtest TFNalpha. Additionally, for later analyses of new or newly relevant parameters/biomarkers aliquots will be stored in the unified biobank hannover. Measurements from arterialized capillary blood: lactate, glucose. Measurement from Saliva: ROS. Questionnaires: WorkAbilityIndex, SF36, nutrition analyses Other Measurements: systolic and diastolic blood pressure Each measurement will be done at baseline and after 6 months.	—

Measure

Time frame

Measurements from venous blood: Oxidative stress (malondialdehyd, nitrate, nirtite), OxLDL, sodium, potassium, calcium, magnesium, phosphate, glucose, bilirubin, creatinine (eGFR), urea, urea acid, cholesterol, LDL cholesterol, HDL cholesterol, triglyceride, creatinkinase, Gamma-GT, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, ferritin, hs CRP, cystatine C, transferrinrezeptor, TSH, NTproBNP, LH, FSH, estradiol, progesterone, ex vivo stimulationtest TFNalpha. Additionally, for later analyses of new or newly relevant parameters/biomarkers aliquots will be stored in the unified biobank hannover. Measurements from arterialized capillary blood: lactate, glucose. Measurement from Saliva: ROS. Questionnaires: WorkAbilityIndex, SF36, nutrition analyses Other Measurements: systolic and diastolic blood pressure Each measurement will be done at baseline and after 6 months.

—

Countries

Germany

Contacts

Public ContactJulian Eigendorf

Medizinische Hochschule Hannover

eigendorf.julian@mh-hannover.de0511 532 9216

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 27, 2026