cytokine elimination as rescue therapy in refractory shock due to sepsis or SIRS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005149

Enrollment

Registered

2013-07-17

Start date

2013-08-17

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

R57.2 R65.9

Interventions

Group 1: Cytokine elimination is used in every case of refractory septic shock as rescue therapy. Therefore we have only one arm. In this study we collect the data of these cases.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Sepsis or SIRS with refractory shock after 4-6 h guideline-based early goal directed therapy

Exclusion criteria

Exclusion criteria: - age < 18 years - IL 6 < 1000 pg/ml - infection with methicillin-resistant staphylococci - infection with vancomycin-resistant enterococci - maximal therapy not indicated (e.g.: limited prognosis due to chronical illness)

Design outcomes

Primary

Measure	Time frame
Change of norepinephrine dose 6 and 12 h after start of Cytosorb(R) compared to the dose at the timepoint of start.	—

Secondary

Measure	Time frame
Organfunctions (SOFA-score), clearance of lactate, vasopressor dependency index	—

Countries

Germany

Contacts

Public ContactSigrun Friesecke

Universitätsmedizn Greifswald

Sigrun.friesecke@uni-greifswald.de03834-8680668

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026