Human low density lipoprotein-metabolism in silico: Modeling the change of lipid-composition in the lipoprotein particle

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005144

Enrollment

Registered

2013-08-12

Start date

2013-08-26

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy participants

Interventions

Group 1: Venous blood-plasma is drawn from healthy probands, who were fasting for 10 hours and have a normal lipoprotein-metabolism, which is not perturbed by medication. The plasma is incubated for d

Eligibility

Sex/Gender

All

Age

20 Years to 55 Years

Inclusion criteria

Inclusion criteria: 20-55 years normolipidemic

Exclusion criteria

Exclusion criteria: use of statins, impaired lipoprotein-metabolism

Design outcomes

Primary

Measure	Time frame
Lipid- and apolipoprotein-concentrations before and after incubation in 6 LDL-subfractions. Established methods are used. Lipids: triglycerides, total cholesterol, free cholesterol, phospholipids. Apolipoproteins: Apolipoprotein B-100, Apolipoprotein A-I, Apolipoprotein A-II, Apolipoprotein E, Lipoprotein LP(a)	—

Secondary

Measure	Time frame
Lipid- and apolipoprotein-concentrations before and after incubation in VLDL, IDL and three HDL-subfractions. Established methods are used. Lipids: triglycerides, total cholesterol, free cholesterol, phospholipids. Apolipoproteins: Apolipoprotein B-100, Apolipoprotein A-I, Apolipoprotein A-II, Apolipoprotein E, Lipoprotein LP(a)	—

Countries

Germany

Contacts

Public ContactMartin Jansen

Univeritätsklinikum Freiburg

martin.jansen@uniklinik-freiburg.de0176-270-35320

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026