Detection of smoking related small airway dysfunction by impulse oscillometry and gas washout tests

Detection of smoking related small airway dysfunction by impulse oscillometry and gas washout tests - IOS-IGW

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005129

Enrollment

150

Registered

2013-07-11

Start date

2013-07-25

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Smoking J44.9

Interventions

Group 1: Healthy non-smoker: Spirometry Bodyplethysmography Single-breath DLCO 3 x Nitrogen multiple breath washout 3 x Double Tracer gas washout with helium and sulfur hexafluorid 3 x Impulse oscill

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: healthy adults: normal spirometry active smoker: smoking history > 10 PY and normal spirometry ex-smoker: no smoking for 12 months, smoking history > 10 PY and normal spirometry

Exclusion criteria

Exclusion criteria: Pulmonary comorbidity, abnormal spirometry, Acute respiratory infection, Pregnancy

Design outcomes

Primary

Measure	Time frame
Significant difference of main Parameters of Impulse Oscillometry (IOS) , Nitrogen multiple breath washout (N2-MBW) and Double Tracer gas washout test with Helium and Sulfur hexafluorid (DTG-SBW) ?	—

Secondary

Measure	Time frame
Association of lung function parameters (IOS, N2-MBW, DTG-SBW) with smoking history (PY)	—

Countries

Germany

Contacts

Public ContactKim Husemann

Klinik Schillerhöhe, Robert-Bosch-Krankenhaus-GmbH Akademisches Lehrkrankenahus der Universität Tübingen

kim.husemann@klinik-schillerhoehe.de++49-7156-203-0

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026