Depressive Episode (F32 ff. ICD 10) Major Depression (296.20 ff. DSM IV) F32 F32.1 F32.2
Conditions
Interventions
Group 1: Bicycle Ergometer Training 3 to 5 days a week for 6 weeks
Group 2: Whole Body Vibration 3 to 5 days a week for 6 weeks
Group 3: Controlgroup "treatment as usual", i.e. those patients who have
Sponsors
Uniklinik Köln, Klinik für Kinder- und Jugendpsychiatrie
Eligibility
Sex/Gender
All
Age
14 Years to 18 Years
Inclusion criteria
Inclusion criteria: Subjects are in-patients of the department of child and adolescent psychiatry, university of Cologne. Age 14-18 years, regardless gender, IQ>70, with normal sports ability. Current depressive disorder has to be diagnosed according to ICD 10 and DSM IV criteria and a baseline score of the DIKJ equal 18.
Exclusion criteria
Exclusion criteria: Psychiatric comorbidities are allowed except of: psychotic disorders, serious personality disorders, serious pervasive developmental disorders, psychosis in the past, current substance abuse, BMI< 16 kg/qm, sports disability, malignant diseases, ongoing medication (with anticonvulsants, steroids, methylphenidate, anti-depressants, neuroleptics, benzodiazepines, mood-stabilizing drugs), Addison’s disease, untreated hypothyreoidism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physical exercise improves depressive symptoms in adolescents, measured by a significant decrease in the DIKJ-Scores (Depression Inventory for Children and Adolescents) under a T-Score of 60 (PR 86,2). Whole Body Vibration shows equivalent or superior effects compared to bicycle ergometer. Measurement points: t0 baseline, t1 after 6 weeks intervention, t2 8-weeks post intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 2. Physical exercise improves in adolescents with depression cognitive functions of the episodic memory measured by an improvement in relevant subtest of the CANTAB® test battery. Whole Body Vibration shows equal or superior effects to bicycle ergometer-training. Measurement points: t0 baseline, t1 after 6 weeks intervention, t2 8-weeks post intervention 3. Physical exercise in adolescents with depression leads to morphological changes in brain regions important for emotion processing and episodic memory and enhances hippocampal volume. Whole Body Vibration shows equal or superior effects to bicycle ergometer-training. Measurement points: t0 baseline, t1 after 6 weeks intervention, t2 8-weeks post intervention 4. Physical exercise in adolescents with depression influences TNF-alpha, IL-6, BDNF and IGF-1. We expect a decrease of TNF-alpha and IGF-1 and an increase of IL-6 and BDNF. Whole Body Vibration shows equal or superior effects to bicycle ergometer-training. Measurement points: t0 baseline, t1 after 6 weeks intervention, t2 8-weeks post intervention 5. Whole Body Vibration shows equal or superior effects to bicycle ergometer-training in the improvement of physical fitness (VO2max and maximum force) in depressed adolecents. Measurement points: t0 baseline, t1 after 6 weeks intervention, t2 8-weeks post intervention | — |
Countries
Germany
Contacts
Public ContactHeidrun Lioba Wunram
Uniklinik Köln, Klinik für Kinder- und Jugendpsychiatrie
Outcome results
None listed