J44
Conditions
Interventions
Group 1: 625 COPD-patients already enclosed in the Cosyconet-Cohort will be scanned in different study centres once by Lowdose-CT and once by MRI with standardized protocols. The images will be pseudo
Sponsors
Universitätsklinikum Heidelberg
Abt. Für Diagnostsiche und Interventionelle Radiologie
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: The trial is fully embedded within the main cohort of the COSYCONET-study: Key inclusion criteria - Male or female - Age >40 years - Diagnosis of COPD (GOLD criteria) - Available for repeated study visits
Exclusion criteria
Exclusion criteria: Having undergone lung surgery (e.g., lung volume reduction, lung transplant); Moderate or severe exacerbation within the last 4 weeks prior to visit 1; Unable to understand the intention of the project; lack of signed informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary goal of this prospective trial is to demonstrate the capability of MRI to replace CT for the characterization of COPD by “structural and functional phenotyping” on a regional basis. The sensitivity and specificity of MRI will be determined by comparison with CT, serving as the gold standard. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are: Relative frequency of completed MRI examinations with diagnostic quality; agreement of visual and software-based phenotyping; comparative assessment of pulmonary functional reserve by perfusion MRI, pulmonary function tests (TLCO); and the six-minute walk test (6 MWT); and extrapulmonary disease manifestations. | — |
Countries
Germany
Contacts
Public ContactKerstin Burmester
Universitätsklinikum Heidelberg, Klinik für Diagnostische und Interventionelle Radiologie, Sektion Pulmonale Radiologie
Outcome results
None listed