Translational examinations of the role of B-Lymphozyte stimulator (BLyS) in the pathophysiology of type 2 diabetes in humans

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005070

Enrollment

Registered

2013-06-14

Start date

2012-10-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E11 E66.9

Interventions

Group 1: weight reduction using a very-low-calorie-diet (VLCD). That means 800 kcal/d for 12 weeks. Laboratory testing at day 0 and week 4 and 12. During the study only blood smaples are to be taken (

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. obesity and/or type 2 diabetes 2. informed consent 3. men and women, 18-80 years of age 4. caucasian descent

Exclusion criteria

Exclusion criteria: 1. lipodystrophy 2. oncological disease 3. LFT >3-fold of normal range 4. creatinin > 1.5 mg/dl 5. Hyper- or hypotcortisolism 6. Hyper- or hypothyreosis 7. known HIV, HBV oder HCV infektion

Design outcomes

Primary

Measure	Time frame
Changes in BLyS erum levels between day 0 and weeks 4 and 12.	—

Secondary

Measure	Time frame
Changes in body weight between day 0 and weeks 4 and 12.	—

Countries

Germany

Contacts

Public ContactMatthias Laudes

UKSH, Campus Kiel Klinik für Innere Medizin 1

matthias.laudes@uk-sh.de0431-597-1380

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026