Prospective observational study for the evaluation of new biomarkers in urine for acute kidney injury after cardiac surgery.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005062

Enrollment

100

Registered

2013-06-12

Start date

2013-06-17

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

N17.9

Interventions

Group 1: 50 adult patients undergoing cardiac surgery with an increased risk for the developement of postoperative acute kidney injury (Cleveland-Score >9). The patients receive the perioperative sta

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 50 adult patients undergoing cardiac surgery with an increased risk for the developement of postoperative acute kidney injury (Cleveland-Score >9). 50 children with congenital heart defects undergoing cardiac surgery

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Immunosuppressive Therapy (within the past 7 days) 3. Hematologcal Precondition 4. HIV infection 5. Acute oder chronic Inflammation 6. Previous organ transplantaion

Design outcomes

Secondary

Measure	Time frame
The secondary outcome of this study is the evaluation of further clinical relevant variables affecting the patients course of the disease: Cardio-pulmonary parameters laboratory data infectiological monitoring medication demographical data The data in this study will be obtained and recorded using standardized data sheets.	—

Primary

Measure	Time frame
The primary outcome of this study is the measurement of the biomarker levels for the detection of acute kidney injury in the patients urine. Urine samples are obtained from the urine cathether (5 ml) for the evaluation of biomarker for the identificaion of acute kidney injury after induction of general anesthesia, and after 4h, 12h, 48h and 96h after the end of the surgical procedure. Additionaly, blood samples are obtained from an intravascular cathether as part of the standard therapy regimen for the measurement of serum creatinine and blood urea nitrogen levels. The following parameter will be measured in urine samples: Hyaluronic acid, KIM-1, NGAL, TIMP-2 (tissue inhibitor of metalloproteinases-2), IGFBP7 (insulin-like growth factor-binding protein 7), GDF-15, other biomarkers and creatinine. The data in this study will be obtained and recorded using standardized data sheets.	—

Measure

Time frame

The primary outcome of this study is the measurement of the biomarker levels for the detection of acute kidney injury in the patients urine. Urine samples are obtained from the urine cathether (5 ml) for the evaluation of biomarker for the identificaion of acute kidney injury after induction of general anesthesia, and after 4h, 12h, 48h and 96h after the end of the surgical procedure. Additionaly, blood samples are obtained from an intravascular cathether as part of the standard therapy regimen for the measurement of serum creatinine and blood urea nitrogen levels. The following parameter will be measured in urine samples: Hyaluronic acid, KIM-1, NGAL, TIMP-2 (tissue inhibitor of metalloproteinases-2), IGFBP7 (insulin-like growth factor-binding protein 7), GDF-15, other biomarkers and creatinine. The data in this study will be obtained and recorded using standardized data sheets.

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Countries

Germany

Contacts

Public ContactAlexander Zarbock

Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie Universitätsklinikum Münster

zarbock@uni-muenster.de++49-251-8347255

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 8, 2026