Determination of antibiotic concentrations in interstitial space fluid of muscle and subcutis in septic patients including a pilot phase

Determination of antibiotic concentrations in interstitial space fluid of muscle and subcutis in septic patients including a pilot phase - DAC-septic patient

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00005046

Enrollment

Registered

2013-07-09

Start date

2013-11-30

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A41.9

Interventions

Group 1: Tissue concentrations of antibiotic were obtained by microdialysis and analysed with HPLC during the 1 - 4 day. Since both are different in sepsis, the protein binding and the distribution of

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Severe sepsis or septic shock as diagnosed according to the criteria of ACCP/SCCM and the MAXSEP Study within 24 hours:

Exclusion criteria

Exclusion criteria: Age < 18 years

Design outcomes

Primary

Measure	Time frame
Area under the concentration time curve (AUC), maximum concentration (Cmax), half-life (t1/2) in the microdialysate and plasma after single dose and at steady state.	—

Secondary

Measure	Time frame
Assoziation of 30 days survival in patients withe sepsis dependent on tussues concentrations of antibiotics. Plasma will be revieled with microdialysis and analysed with HPLC.	—

Countries

Austria, Germany

Contacts

Public ContactMichael Adamzik

Knappschaftskrankenhaus Bochum Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie

anaesthesie@kk-bochum.de02342993001

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026