Personalised Prognostic Tools for Early Psychosis Management

Conditions

Individuals in a clinically defined at-risk mental state for psychosis healthy volunteers F20 F22 F23 F25 F28 F29 F31.2 F32.3 F32

Wenzel J, Badde L, Haas SS, Bonivento C, Van Rheenen TE, Antonucci LA, Ruef A, Penzel N, Rosen M, Lichtenstein T, Lalousis PA, Paolini M, Stainton A, Dannlowski U, Romer G, Brambilla P, Wood SJ, Upthegrove R, Borgwardt S, Meisenzahl E, Salokangas RKR, Pantelis C, Lencer R, Bertolino A, Kambeitz J, Koutsouleris N, Dwyer DB, Kambeitz-Ilankovic L, PRONIA consortium.

2023-09-2212 citations

10.1038/s41386-023-01729-7

Detailed clinical phenotyping and generalisability in prognostic models of functioning in at-risk populations

Marlene Rosen, Linda T. Betz, Natalie Kaiser, Nora Penzel, Dominic Dwyer et al. (20 authors)

The British Journal of Psychiatry2021-10-062 citations

10.1192/bjp.2021.141

Interventions

Group 1: Observation group (naturalistic design) including ROP patients, ROD patients, individuals in an at-risk mental state for psychosis and healthy volunteers Examinations: In all subjects: - Blo

Eligibility

Sex/Gender

All

Age

15 Years to 40 Years

Inclusion criteria

Inclusion criteria: Recent-onset psychosis (ROP): • EITHER (i) transition criteria as defined by Yung et al. (1998) • OR (ii) ICD-10: F20.x, F22.x, F23.x, F25.x, F28, F29, F31.2, F32.3 Recent-onset depression (ROD): • ICD-10: F32.x At-risk mental states for psychosis (ARMS): • EITHER (i) CAARMS criteria • OR (ii) SPI-A criteria • OR (iii) GAF reduction = 30% and positive family history of psychoses • OR (iv) GAF reduction = 30% and criteria for schizotypia (ICD-10: F21) Controllgroup: • healthy volunteers without a personal history of affective or non-affective psychoses or other psychiatric conditions and no family history of psychoses (1° relatives)

Exclusion criteria

Exclusion criteria: General exclusion: • Age 40 • IQ 12 months • Duration of antipsychotic medication > 3 months ROD: • Inclusion criteria for ROP and ARMS • Duration of depressive episode > 12 months ARMS: Inclusion criteria for recent-onset psychoses HC: • Personal history of affective or non-affective psychoses or other psychiatric conditions • Family history of psychoses (1° relatives)

Design outcomes

Primary

Measure	Time frame
Sensitivity and Specificity of prognostic system	—

Secondary

Measure	Time frame
Individuals diagnostic load / cost effectiveness of prognostic system	—

Countries

Finland, Germany, Italy, Switzerland, United Kingdom

Contacts

Public ContactNikolaos Koutsouleris

Department of Psychiatry and Psychotherapy Ludwig-Maximilian-University

nikolaos.koutsouleris@med.uni-muenchen.de+49 89 5160 5885

Outcome results

None listed