Healthy subjects G20 G63.2
Conditions
Interventions
Group 1: In study arm 1, 24 patients with diabetic neuropathy will undergo the QPART method on both volar forearms. (Siepmann et al. Archives of Neurology 2012).
Comparative standard autonomic measure
Sponsors
Institut für Klinische Pharmakologie
Medizinische Fakultät Carl Gustav Carus
Technische Universität Dresden
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Male and female patiens with diabetic neuropathy ages 18-75 years will be inculded following full written informed consent. Furthermore male and female healthy control subjects as wella as male and female patiens with Parkinson's disease ages 18-75 years will be inculded following full written informed consent. Each diagnosis (Parkinsion's disease or diabetic neuropathy) has to be cproven previously.
Exclusion criteria
Exclusion criteria: Patient arms: - intake of beta-blockers within 14 days previous to beginning of the study - intake of antidepressants within 3 months previous to beginning of the study - dermatologic comorbidities affecting the testing sites - known allergy to phenylephrine - consumption of more than 10 cigarettes per day - consumption of one alcoholic beverage per day - consumption of any nicotine, caffeine or alcohol at the testing day Control arm: -any acute of chronic disease -chronic intake of medication - consumption of more than 10 cigarettes per day - consumption of one alcoholic beverage per day - consumption of any nicotine, caffeine or alcohol at the testing day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of hair follicle silicone indentations - analysis through counting of the indentation in silicon scans- analysis on the day of measurement | — |
Secondary
| Measure | Time frame |
|---|---|
| Volume and area spread of hair follicle silicone indentations - analysis through digital image analysis of the indentations in silicon scans- analysis on the day of measurement | — |
Countries
Germany
Contacts
Public ContactTimo Siepmann
Klinik und Poliklinik für Neurologie Universitätsklinikum Carl Gustav Carus
Outcome results
None listed