G25.0
Conditions
Interventions
Group 1: Age- and gender-matched controls, whose time perception is measured once
Group 2: ET-patients without deep brain stimulation whose time perception is measured once
Group 3: ET-patients with d
Sponsors
Klinik und Poliklinik für Neurologie
Universitätsklinik zu Köln
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age- and sex-matched control probands: Age between 18-80 years ET-patients without Deep Brain Stimulation: Patients with essential tremor (ET) fulfilling the criteria of the consensus statement of the Movement Disorder Society Age between 18-80 years Disease duration of at least 5 years ET-patienten with Deep Brain Stimulation: Patients with essential tremor (ET) fulfilling the criteria of the consensus statement of the Movement Disorder Society and DBS for at least 3 months Age between 18-80 years Disease duration of at least 5 years Electrode localisation in the ventrolateral thalamus or areas just below (posterior subthalamic area, PSA) Tolerabel tremor after switching off the stimulation
Exclusion criteria
Exclusion criteria: Age- and sex-matched controls: Subjects with a severe neurologic disease (e.g. epilepsy, brain tumor, ischaemic stroke, dystonia) Conspicuities in the MRI Medication affecting cognition which cannot be withdrawn for at least 24 hours Hypokinesia or resting tremor possibly indicating an underlying Parkinson's disease DemTect < 9 Severe depression ET-patients without Deep Brain Stimulation: Patients with a severe neurologic disease other than essential tremor (e.g. epilepsy, brain tumor, ischaemic stroke, dystonia) Conspicuities in the MRI Medication affecting cognition which cannot be withdrawn for at least 24 hours Hypokinesia or resting tremor possibly indicating an underlying Parkinson's disease DemTect < 9 Severe depression ET-patients with Deep Brain Stimulation: Patients with a severe neurologic disease other than essential tremor (e.g. epilepsy, brain tumor, ischaemic stroke, dystonia) Medication affecting cognition which cannot be withdrawn for at least 24 hours Hypokinesia or resting tremor possibly indicating an underlying Parkinson's disease DemTect < 9 Severe depression
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time perception is measured with a self programmed software once in ET-patients and control subjects. Additionally, ET-patients with DBS are tested during three different stimulation regimes in a randomized order. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fahn Tolosa Marin Tremor Rating Score (TRS) is measured objectively via Video ratings and ultrasound based measurements | — |
Countries
Germany
Contacts
Public ContactDavid J. Pedrosa
Universitätsklinik Köln Klinik und Poliklinik für Neurologie AG Bewegungsstörungen
Outcome results
None listed