Cardiovascular effects of aerobic and isometric exercise in patients with arterial hypertension

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00004911

Enrollment

Registered

2013-04-29

Start date

2013-02-27

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I10

Interventions

Group 1: Active handgrip exercise, 5 days per week, 8 minutes per day for 12 weeks. After the completion of the first phase (12 weeks), the patients begin with endurance training while continuing the

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Presence of hypertension under drug therapy or = 140/90 mmHg without antihypertensive therapy. Furthermore, walking ability, adequate linguistic knowledge, age>18 years, ability to give informed consent.

Exclusion criteria

Exclusion criteria: High grade peripheral vascular disease (> stage 1), Aortenvitium (> grade 1), hypertrophic obstructive cardiomyopathy, high grade heart failure (> NYHA II), uncontrolled cardiac arrhythmias, systolic resting blood pressure = 180 mmHg and / or diastolic resting blood pressure = 110mmHg , participation in other clinical trial. For performing the handgrip exercise patients with advanced arthritis in the hands or acute Medianus Kompression Syndrom will be excluded.

Design outcomes

Primary

Measure	Time frame
Reduction of systolic and diastolic blood pressure in the clinic and ambulatory 24-hour blood-pressure measurement after the exercise training (12 weeks).	—

Secondary

Measure	Time frame
Changes in endothelial function measured by FMD (flow mediated dilation). Changes of the arterial stiffness by applanation tonometry with the HEM9000-AI unit of the company Omron. Determination of the augmentation index (AI). Elasticity index of large arteries (systemic arterial compliance), elasticity index of small arteries (arterial compliance by oscillometry), total peripheral resistance and cardiac output by pulse wave analysis using the HDI / Pulse Wave ™. Blood sampling for determination of nitrite, nitrate, superoxide dismutase and endothelial progenitor cells (EPC). All these examinations take place before and after the first phase of the study (12 weeks). Patients who take part in the second phase (add-on therapy) will undertake the same examinations once more 24 weeks after recruitment in the trial.	—

Measure

Time frame

Changes in endothelial function measured by FMD (flow mediated dilation). Changes of the arterial stiffness by applanation tonometry with the HEM9000-AI unit of the company Omron. Determination of the augmentation index (AI). Elasticity index of large arteries (systemic arterial compliance), elasticity index of small arteries (arterial compliance by oscillometry), total peripheral resistance and cardiac output by pulse wave analysis using the HDI / Pulse Wave ™. Blood sampling for determination of nitrite, nitrate, superoxide dismutase and endothelial progenitor cells (EPC). All these examinations take place before and after the first phase of the study (12 weeks). Patients who take part in the second phase (add-on therapy) will undertake the same examinations once more 24 weeks after recruitment in the trial.

—

Countries

Germany

Contacts

Public ContactStergios Vlatsas

Charité Campus Benjamin Franklin

stergios.vlatsas@charite.de03084452623

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026