C50 C81
Conditions
Interventions
Group 1: Women after radiation of hodgkin´s disease in childhood and adolescence including breast area from 25 years of age:
- Instruction for self-examination of the breast
- Every 6 months medical
Sponsors
Uniklinik Köln
Eligibility
Sex/Gender
Female
Age
25 Years to 50 Years
Inclusion criteria
Inclusion criteria: Main inclusion criteria: - = 25 years - female - radiation including breast area in childhood and adolescence due to HD at the age of 9 - 17 years - no contraindication against one of the diagnostic procedures - able to give informed consent
Exclusion criteria
Exclusion criteria: - = 50 years of age - pregnancy, lactation - contraindication for MRI of the breast (e.g. contrast agent allergy, pacemaker, defibrillator, epicardial wires, certain cochlear and ocular implants and heart valves, magnetically activated tissue expanders, tattoos containing metal in the examination area or osteosynthesis material due to the risk of overheating, patient at risk of nephrogenic systemic fibrosis)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prospective incidence of secondary breast cancers in women after radiation of Hodgkin´s disease including breast area in childhood and adolescence | — |
Secondary
| Measure | Time frame |
|---|---|
| - Value (sensitivity, specificity, positive predictive value, negative predictive value) of the diagnostic procedures breast sonography, mammography, magnetic resonance imaging of the breast - Early detection of secondary breast carcinomas - Influence of early detection on breast carcinoma mortality | — |
Countries
Germany
Contacts
Public ContactKerstin Rhiem
Zentrum Familiärer Brust- und Eierstockkrebs
Outcome results
None listed