I71.2 I35.1
Conditions
Interventions
Group 1: Quantification of local mechanical wall characteristics using magnetic resonance imaging and correlation with serum levels of aortic wall-associated proteins.
Sponsors
University Heart Center Freiburg
Eligibility
Sex/Gender
All
Age
15 Years to 75 Years
Inclusion criteria
Inclusion criteria: Age 15-75 years, bicuspid or tricuspid aortic valve, non-syndromic patients, all types of Marfan- or Loeys-Dietz-Syndrome, all Stanford-Fazel clusters of bicuspid aortic valve-associated aortopathy, all Sievers-classes of bicuspid aortic valve, aneurysm of the aortic root, ascending aorta or aortic arch, aneurysm etiologies: degenerative, calcified, Syndrome-associated
Exclusion criteria
Exclusion criteria: Children with congenital aortic valve vitium or under 15 years of age, age over 75 years, connective tissue diseases other than Marfan- or Loeys-Dietz-Syndrome, Stanford Type A or B aortic dissection, active malign disease, congenital plasmatic coagulation disorders, prior aortic valve replacement, prior thoracic aortic stengrafting (TEVAR), prior conventional thoracic aortic prosthetic replacement, aneurysm etiologies: chronic dissecting, infectious, luetic, false aneurysms, isolated sinus valsalva aneurysm
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Shear-stress and wall-tension in thoracic aortic aneurysms using flow-sensitive magnetic resonance imaging before operative procedure | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels of aortic media-associated structural and functional proteins before operative procedure | — |
Countries
Germany
Contacts
Public ContactFabian A. Kari
University Heart Center Freiburg
Outcome results
None listed