I67.9
Conditions
Interventions
Group 1: 1. Education about a healthy lifestyle (physical activity, nutrition) in a seminar.
2. Examination 1 (before training)
3. Three month training phase, three one-hour sessions per week. Exercis
Sponsors
Neurologische Klinik
UniversitätsMedizin Mannheim
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. No regular physical activity before inclusion 2. Willingness to participate regularly
Exclusion criteria
Exclusion criteria: 1. Preexisting physical (orthopedic or cardiologic) conditions, precluding participation in training 2. Preexisting functionally relevant neurologic disorder 3. Preexisting functionally relevant psychiatric disorder 4. MoCA <26 5. Contraindication against MRI scanning 6. MRI-evidence of a structural brain lesion or vascular pathology interfering with fMRI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in quality of life (Wellbeing Five) from examination 1 to examination 2 comparing the training and the control group (timepoints of examinations see arm1 and arm2) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in parameters B-K from examination 1 to examination 2 comparing the training and control group will be analyzed. 2. Change in parameters A, C, D, F-K comparing all participants (from examiantion before training to examination after training) with the control group (from the examination before control to the examination after control) will be analyzed. 3. Change in parameters A-K from the examination after the 3-month training to the last examination comparing the group of participants continuing the training and the group of participants abandoning the training will be analyzed. A. Quality of life (Wellbeing Five) B. Cognitive performance (TMT-A&B, VLMT, verbal fluency, CANTAB battery) C. Physical performance (spiroergometry, vigorimeter) D. Stance and gait testing (computed gait analysis, SPPB, gait velocity, single leg stance time) E. Functional brain performance (1-back, 2-back fMRI) F. Resting state networks (low-BOLD-fluctuations) G. Structural brain changes: atrophy, cerebral small vessel disease, connectivity (MP-RAGE, FLAIR, SWI, DTI) H. Body composition and risk profile (BIA, hip-waist-ratio, BMI, blood pressure, glucose, cholesterol) I. Quality of life (SF-36) J. Sleep quality (FOSQ) K. Nutrition (Nutriwell Check) | — |
Countries
Germany
Contacts
Public ContactMartin Griebe
Neurologische Klinik UniversitätsMedizin Mannheim
Outcome results
None listed