Incidence of nosocomial blood stream infections, antibiotic resistances and blood culture ordering and testing practices – a Thuringia-wide prospective population-based study

Incidence of nosocomial blood stream infections, antibiotic resistances and blood culture ordering and testing practices – a Thuringia-wide prospective population-based study - AlertsNet

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00004825

Enrollment

25000

Registered

2013-04-19

Start date

2013-09-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

R65.0 R65.1 A41.0 A41.1 A41.2 A41.3 A41.4 A41.5 A41.8 A41.9 A41

Interventions

Group 1: All Thuringian hospiatals with blood culture diagnostics can take part in the surveillance. Currently, 30 clinical facilities are involved as well as 16 microbiological labs. Population Basis

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with positive blood culture

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
Primary goal is the development and explorative validation of adjusted indicators for quality assurance in case of bloodstream infection with an aim at sufficient and indication-related diagnostics. The following indicators are to be evaluated under consideration of the specific characteristics and the case-mix in the clinical facilities: To get an overview: Incidence rate of all episodes with in minimum 1 positive blood culture / sepsis incident (number/1,000 patient days) Incidence rate of all nosokomial episodes with in minimum 1 positive blood culture / sepsis incident (number/1,000 patient days). In addition to the frequently used indicators that describe resistances to different bacteria in blood cultures in percentage terms, a number of further indicators are proposed: Incidence rate of CVC-associated blood stream infections (primary sepsis) (number/1,000 CVC-days), Incidence rate of urinary catheter-associated blood stream infections (secondary sepsis) (number/1,000 urinary catheter-days), Incidence rate of ventilator-associated pneumonia and associated blood stream infections (secondary sepsis) (number/1,000 ventilation days), Incidence rate of positive blood cultures (number/1,000 blood culture sets), and Incidence rate of total number of blood culture sets taken (number/1,000 patient days and sending institution). To capture the degree of antibiotic resistance: Incidence rate of positive blood cultures with resistant pathogens (number/1,000 patient days), Incidence rate of positive blood cultures in case of nosokomial bloodstream infection with resistant pathogens (number/1,000 patient days). To determine process quality: Incidence rate of blood culture sets totally taken (number/1,000 patient days and posting facility), Number of patients with drawn blood culture sets (number/1,000 patient days), Number of blood culture sets per episode and per patient (number/episode and patient). The reference values for incidence rates of blood culture sets tha	—

Measure

Time frame

Primary goal is the development and explorative validation of adjusted indicators for quality assurance in case of bloodstream infection with an aim at sufficient and indication-related diagnostics. The following indicators are to be evaluated under consideration of the specific characteristics and the case-mix in the clinical facilities: To get an overview: Incidence rate of all episodes with in minimum 1 positive blood culture / sepsis incident (number/1,000 patient days) Incidence rate of all nosokomial episodes with in minimum 1 positive blood culture / sepsis incident (number/1,000 patient days). In addition to the frequently used indicators that describe resistances to different bacteria in blood cultures in percentage terms, a number of further indicators are proposed: Incidence rate of CVC-associated blood stream infections (primary sepsis) (number/1,000 CVC-days), Incidence rate of urinary catheter-associated blood stream infections (secondary sepsis) (number/1,000 urinary catheter-days), Incidence rate of ventilator-associated pneumonia and associated blood stream infections (secondary sepsis) (number/1,000 ventilation days), Incidence rate of positive blood cultures (number/1,000 blood culture sets), and Incidence rate of total number of blood culture sets taken (number/1,000 patient days and sending institution). To capture the degree of antibiotic resistance: Incidence rate of positive blood cultures with resistant pathogens (number/1,000 patient days), Incidence rate of positive blood cultures in case of nosokomial bloodstream infection with resistant pathogens (number/1,000 patient days). To determine process quality: Incidence rate of blood culture sets totally taken (number/1,000 patient days and posting facility), Number of patients with drawn blood culture sets (number/1,000 patient days), Number of blood culture sets per episode and per patient (number/episode and patient). The reference values for incidence rates of blood culture sets tha

—

Secondary

Measure	Time frame
Linking of all stationary facilities and microbiological labs in Thuringia to get access to representative data of the residents of the federal state. Development of an electronic detection system for a timely survey on data from blood culture diagnostics. Capture of selected clinical characteristics of patients with nosokomial bloodstream infection (primary and secondary sepsis) to describe the degree of sepsis-associated morbidity and mortality.	—

Measure

Time frame

Linking of all stationary facilities and microbiological labs in Thuringia to get access to representative data of the residents of the federal state. Development of an electronic detection system for a timely survey on data from blood culture diagnostics. Capture of selected clinical characteristics of patients with nosokomial bloodstream infection (primary and secondary sepsis) to describe the degree of sepsis-associated morbidity and mortality.

—

Countries

Germany

Contacts

Public ContactRoland Schmitz

Integriertes Forschungs- und Behandlungszentrum (IFB) Sepsis und Sepsisfolgen, Center for Sepsis Control and Care (CSCC), Universitätsklinikum Jena

roland.schmitz@med.uni-jena.de+49-3641-9396694

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 10, 2026