Long-term Cognitive and Funtional Outcome of Survivors of severe Sepsis following a computerized Cognitive Training

Long-term Cognitive and Funtional Outcome of Survivors of severe Sepsis following a computerized Cognitive Training - LOSS-Cog-Train

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00004815

Enrollment

300

Registered

2013-05-02

Start date

2013-05-03

Completion date

Unknown

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis A41.9 F06.7

Interventions

Group 1: ambulant standard therapy only in control group (e.g. physiotherapy, occupational therapy) Group 2: intervention: cognitive training based on computerized cognitive training program (Cog-Trai

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Survivors of severe sepsis or septic shock 2. Impaired cognitive functions exist up to two years post Sepsis, which make an intervention reasonable (at least one test of the neuropsychological test battery has a percentile less than 16). 3. signed informed consent

Exclusion criteria

Exclusion criteria: 1. Patients after an acute event which effects the central nervous system (i.e. stroke, meningitis, intracranial bleeding) 2. Patients with preexisting disease or brain injury affecting cognitive (like Parkinson-dementia complex, HIV-encephalopathy, multiple sclerosis stroke or traumatic brain injury, psychiatric disorder) 3. Patients with severe paresis as a consequence of critical illness polyneuropathy and/or myopathy who can´t handle the computer at time point of randomization 4. Patients with a serious cognitive impairment at time point of randomization (Mini Mental State Exam score </= 20 points) 5. Patients who answer no to question about computer affinity 6. Patients who are included in an other clinical trial 7. Psychotropic co-medication at time point of randomization (like Neuroleptica and Benzodiacepine) which can reduce cognitive function

Design outcomes

Primary

Measure	Time frame
cognitive function at 3 and 9 months after randomization (neurophysiological tests with a test battery corresponding to individual impairment specific deficites)	—

Secondary

Measure	Time frame
1) Executive cognitive function at 3 and 9 months after randomization, measured by Tower test (Delis et. al. 2004) 2) Functional disability at 3 and 9 months after randomization, evaluated by ADL and IADL according to Iwashyna et. al. 2010 3) impact on cognitive function and functional disability of age, length from beginning of sepsis until study recruitment (in days)	—

Countries

Germany

Contacts

Public ContactFarsin Hamzei

Moritz-Klinik Bad Klosterlausnitz

neuro@moritz-klinik.de+49 (0)36601 49 471

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026