Diaphragmatic strength during respiratory muscle training in weaning patients

Diaphragmatic strength during respiratory muscle training in weaning patients - TracheoTwitch

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00004813

Enrollment

Registered

2013-05-22

Start date

2013-06-03

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J96.19

Interventions

Group 1: Following the explanation of the study and the signing of the informed consent of the participant on the day prior to the measurement, the patient is transferred to mechanical ventilator, sui

TwPet will be performed following every second RMT session (T1, T2), as well as 5min (T3) and 15min (T4) post RMT. At the above mentioned time points physiological parameters will be assessed as follo

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Prolonged Weaning according to the criteria of Boles et al Weaning from mechanical ventilation. Eur Respir J. 2007; 29: 1033-56. Ability fo spontaneus unassisted breathing for at least one hour Informed consent Supplied with a tracheostomy tube At least 18 years of age

Exclusion criteria

Exclusion criteria: Severe hypoxic respiratory insufficiency(PaO2 0.40) Hemodynamic instability within the previous 24h to the study with increased levels of catecholamines (Dobutamin > 5 mg/kg/min, Noradrenalin > 1 mg/kg/min) Previous known neuromuscular diseases (other than critical illness polyneuropathy (CIP)/-myopathy (CIM), intensive care unit acquired weakness (ICUAW)) Lacking cooperation Implanted metal devices in the head/neck region Orthopedic or other limitations for a sitting position Use of sedative or analgetic medication within 6 hours prior to the measurement Indication to use a PEEP-ventile for unassisted spontaneous breathing Body Mass index > 30 kg/m2

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the course of tracheal-canula airway pressure (TwPet (Powerlab, AdInstruments Pty, Castle Hill, Australien)) during bilateral anterior magnetic phrenic nerve stimulation (BAMPS(Magstim 2002, Magstim Inc. ,Wales, United Kingdom)) pre and post respiratory muscle training (IMT) at the time points T0 (before training) and T2 (after 4 RMT sessions).	—

Secondary

Measure	Time frame
The course of maximal static inspiratory pressure (PImax), electrical respiratory muscle activation as assessed by electroymography (EMG), blood gas parameters, subjective dyspnea and strength assessment (modified Borg Dyspnea Scale), breathing rate, heart rate, blood pressure during respiratory muscle training at the time points T0 (before training), T1 (after 2 RMT sessions, T2 (after 4 RMT sessions, T3 and T4 (5min and 15min post RMT).	—

Measure

Time frame

The course of maximal static inspiratory pressure (PImax), electrical respiratory muscle activation as assessed by electroymography (EMG), blood gas parameters, subjective dyspnea and strength assessment (modified Borg Dyspnea Scale), breathing rate, heart rate, blood pressure during respiratory muscle training at the time points T0 (before training), T1 (after 2 RMT sessions, T2 (after 4 RMT sessions, T3 and T4 (5min and 15min post RMT).

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Countries

Germany

Contacts

Public ContactStephan Walterspacher

Uniklinik Freiburg Abt. Pneumologie

stephan.walterspacher@uniklinik-freiburg.de+49 761 270 37140

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026