F00 F20.0 F32.1 F32.2 F33.1 F33.2 F31
Conditions
Interventions
Group 1: Exom Sequencing of the patients with aforesaid psychiatric disorders
Sponsors
Abtl. Psychiatrie und Psychotherapie, Universitätsklinikum Freiburg
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) The ICD-10 criteria must be fulfilled for following disorders a) Schizophrenia, paranoid type b) Major depression c) bipolar affective Disorder d) Alzheimer's Disease 2) There has to be a previous episode of the diseases a), b), c) 3) The minimum age presupposed 18 years (legal age)
Exclusion criteria
Exclusion criteria: 1) Axis II Disorder 2) Axis I Co- Morbidity 3) Chronical Progress 4) Maximum age presupposed 65 years for the diseases a), b), c)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| global sequencing of all Reelin associated genes and reestablish a gene databbase with intent to detect - gene polymorphism of the reelin system in psychiatric patients - de novo mutaions - specific mutations, which were detected by the other subprojects | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of hippocampal declerative Memory, Amygdala associated fear conditioning, cortical synaptic excitability and the results of brain imaging | — |
Countries
Germany
Contacts
Public ContactTobias Hornig
Universitätsklinikum Freiburg, Abteilung für Psychiatrie und Psychotherapie
Outcome results
None listed