The effect of stimulus patterns on the mismatch negativity in patients with schizophrenia

The effect of stimulus patterns on the mismatch negativity in patients with schizophrenia - Predict

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00004756

Enrollment

Registered

2013-02-26

Start date

2013-03-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

DSM-IV 295.30 Schizophrenia, paranoid type DSM-IV 295.10 Schizophrenia, disorganized type DSM-IV 295.90 Schizophrenia, undifferentiated type DSM-IV 295.60 Schizophrenia, residual type DSM-IV 295.40 Schizophreniform disorder DSM-IV 295.70 Schizoaffective disorder DSM-IV 297.1 Delusional disorder F20 F25 F22

Interventions

Group 1: Patients: A electrophysiological and clinical measurement (SKID, PANSS) are used. Futhermore we conduct neuopsychological tests (MWT-B, ZST, SKT, TMT A/B, WMS-R). The electrophysiological mea

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Patients: DSM-IV Schizophrenia diagnosis: 295.30, 295.10, 295.9, 295.60, 295.40, 295.70, 297.1; Patients: stable medication since two weeks; healthy controls: no psychiatric disorder (for example a major depression); MWT-B IQ > 75; fluency of German language; voluntary written consent

Exclusion criteria

Exclusion criteria: Impaired hearing; neurological or neurodegenerative disorder, persisting or past substance abuse; acut or chronic inflammatory disease of the nervous system, other serious physical diseases or malignant tumors

Design outcomes

Primary

Measure	Time frame
Primary outcome is the amplitude of the mismatch negativity in the lantency range of 120 ms to 260 ms following stimulus onset	—

Secondary

Measure	Time frame
Secondary outcome is the performance in study participants in the neuropsychological assessment and the expression of clinical symptoms as assessed with the Positive and Negative Syndrome Scale (PANSS). Neuropsychological assessments include: The German Merfachwahl Wortschatz Test (MWT-B), the Digit Symbol Test (ZST), Syndrome short Test (SKT) and the Trail Making Test Part A +B (TMT A/B).	—

Countries

Germany

Contacts

Public ContactMagdalena Breitkopf

Klinik für Psychiatrie und Psychotherapie, LVR-Klinikum Essen, Universität Duisburg-Essen

magdalena.breitkopf@uni-due.de+49 201 9597012

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026