G80
Conditions
Interventions
Group 1: Lengthening of the knee flexors by tendinous lengthening of the semitendinosus muscle combined with a fractional lengthening of the semimembranosus and gracilis muscles
Group 2: Lengthening o
muscle biopsies of subject ondergoing surgery in the hamstring region (e.g. cruciate ligament reconstruction)
Sponsors
VU University Medical Center Department of Rehabilitation Medicine
Eligibility
Sex/Gender
All
Age
6 Years to 20 Years
Inclusion criteria
Inclusion criteria: (1.) Clinical diagnosis of spastic cerebral palsy; (2.) Indication for surgical lengthening of thigh and/or calf muscles; (3.) Gross Motor Function Classification System Class I-III (ability to walk with or without aids);
Exclusion criteria
Exclusion criteria: (1.) Treatment of muscles, which are indicated for surgical procedures, with Botuline A-Toxine within three months before surgery; (2.) A pre-surgical treatment with selective dorsal rhizotomy, intrathecal baclofen pump or prior surgery of treated muscle; (3.) Major disease or accident one year prior to measurements or a disturbed normal activity level of the child for more than three weeks in the last half year; (4.) 24-hour casting for more than two weeks, that includes the treated muscle three month prior to surgery; (5.) Additional neuromuscular, orthopaedic, inflammatory or systemic diseases which can influence walking ability or muscle properties; (6.) Medication that influences neuromuscular properties three month prior to surgery; (7.) Parents/guardians or child do not cooperate well enough to take part in the project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Histological, morphological and mechanical properties of the treated muscles and tendons, and angle-moment relationship. These will be determined by muscle and tendon biopsies, muscle ultrasound measurements and moment-angle measurements. Measurements will be performed before surgery (baseline), 6-12 weeks, 6 month, 12 month and 24 month after surgery. Muscle and tendon biopsies will be taken only once, during surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical, gait, and functional characteristics. Following measurements will be used: Gross Motor Function Measurement (GMFM), 6-minute walk test, Functional Mobility Scale (FMS), Mobility Questionnaire (MobQuest28), Mobility part of the Pediatric Evaluation Disability Inventory (PEDI), clinical physical examination and gait analysis. Measurements will be performed before surgery (baseline), 6-12 weeks, 6 month, 12 month and 24 month after surgery. | — |
Countries
Netherlands, Switzerland
Contacts
Public ContactErich Rutz
Universitäts-Kinderspital beider Basel
Outcome results
None listed