J45.9 J45.0 J45.8
Conditions
Interventions
Group 1: Allergic asthmatics
(clinical examination, lung funciton, measurement of exhaled nitric oxide, blood withdrawal, throat swab)
Group 2: Non-allergic asthmatics
(clinical examination, lung fun
Sponsors
Dr. von Haunersches Kinderspital
Eligibility
Sex/Gender
All
Age
4 Years to 17 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Age 4-17, recurrent pulmonary infections with airway obstruction / wheeze, more than 3 doctor´s diagnosed obstructive bronchitis. Intake of short-or long- acting beta 2-agonists, inhaled corticosteroides, leukotriene antagonists. Detailed clinical examination including lung-function.
Exclusion criteria
Exclusion criteria: Exclusion criteria for asthmatics: Any other pulmonary diseases (e.g. cystic fibrosis, bronchopulmonary dysplasia), any other chronic diseas, autoimmune diseases, immune deficiency, fever 14 day before inclusion, intake of antibiotics and probiotics 14 day before inclusion, intake of corticosteroides 14 days before inclusion, hypersensitization-therapy. /// Exclusion criteria for healthy controls: Any pulmonary diseases (e.g. cystic fibrosis, bronchopulmonary dysplasia), any allergic diseases, any other chronic diseas, autoimmune diseases, immune deficiency, fever 14 day before inclusion, intake of antibiotics or probiotics 14 day before inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Characterization of T cell marker | — |
Secondary
| Measure | Time frame |
|---|---|
| Characterization of immune regulation in peripheral blood mononuclear cells | — |
Countries
Germany
Contacts
Public ContactBianca Schaub
Dr. von Haunersches Kinderspital
Outcome results
None listed