Perfusion of peripheral muscles during isolated exercise of respiratory muscles in hypoxia and normoxia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00004631

Enrollment

Registered

2013-01-10

Start date

2013-01-09

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle perfusion of the lower extremity in hypoxia and normoxia during inspiratory muscle loading in healthy volunteers Comparison of arterial blood flow and muscle perfusion during respiratory muscle loading healthy volunteers

Interventions

Group 1: Pre-measurements: To begin, subjects perform a bodyplethysmography and measurement of maximal inspiratory mouth pressure (Pimax) to assess respiratory muscle strength. Then diphragmatic stren

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age > 18 years, normal lung function

Exclusion criteria

Exclusion criteria: acute coronary syndrome, congenital heart defects, pulmonal hypertension, neuromuscular diseases, deformities of the thorax, respiratory infections, pregnancy and lactation, cardiac pacemaker, AICD, electric / metal implants

Design outcomes

Primary

Measure	Time frame
Difference in contrast medium travel time after 20 minutes of inspiratory muscle loading in hypoxia in contrast to normoxia.	—

Secondary

Measure	Time frame
Difference in blood flow (assessed by duplex sonography) after 20 minutes of inspiratory muscle loading in hypoxia in contrast to normoxia.	—

Countries

Germany

Contacts

Public ContactDavid Walker

Abteilung Pneumologie Uniklinik Freiburg

david.walker@uniklinik-freiburg.de+49 761 270-37140

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026