Postoperative pain intensity and morphine consumption after elective lower abdominal surergy
Conditions
Interventions
Group 1: “low dose remifentanil plus preoperative saline” (RL): a remifentanil infusion was maintained at a rate of 0,1 µg kg-1 min-1 throughout anaesthesia, whereas the endtidal Vol.-% of sevoflurane
preoperatively 500ml NaCl 0,9% were infused as study solution
Group 2: “high dose remifentanil plus preoperative saline” (RH): the endtidal Vol.-% of sevoflurane was maintained at 0,5 MAC throughout a
a remifentanil infusion was started at a rate of 0,2 µg kg-1 min-1 and subsequently increased by 0,05 µg kg-1 min-1 increments to clinical demand
preoperatively these patients also received an infusion of 500ml NaCl 0,9% as study solution
Group 3: “high dose remifentanil plus preoperative amantadine” (RHA): the same anaesthetic protocol as grou
Sponsors
Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin, Campus Charite Mitte und Virchow Klinikum, Charite - Universitätsmedizin Berlin
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) patients of at least 18 years; 2) American Society of Anaesthesiologists physical Status I – II; 3) open surgical procedures of the lower abdomen [(hemi-)colectomy, anterior rectum resection; abdominoperineal rectum resection; radical prostatectomy (RPX)] with an anticipated duration of anaesthesia of at least 90 minutes
Exclusion criteria
Exclusion criteria: (1) were operated by laparoscopy; (2) had to be transfused with = 2 units of packed red blood cells; (3) could not be extubated immediately after surgery; (4) had a chronic inflammatory disease, including inflammatory bowel disease; (5) had acute infection and/or SIRS/Sepsis; (6) had used opioids within 12 h before surgery4; (7) had a history of drug or alcohol abuse, psychiatric disorders or obesity (BMI > 30 kg/m2); (8) had contraindications to the self-administration of opioids (i.e., patients were unable to understand the patient-controlled intravenous analgesia [PCIA] device or had obstructive sleep apnea syndrome); (9) had contraindications to the use of amantadine (e.g., heart rhythm or conductance disturbance, renal insufficiency, epilepsy, delirium)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain intensity measured by numerical rating scale (NRS) in the 0./1./2./3./4./6. hour with PCIA | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative morphine consumption measured in milligramm in the 0./1./2./3./4./6. hour with PCIA | — |
Countries
Germany
Contacts
Public ContactSascha Treskatsch
Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin, Campus Charite Mitte und Virchow Klinikum, Charite - Universitätsmedizin Berlin
Outcome results
None listed