Influence of non-surgical and surgical orthopedic treatment on stress and depression levels, sympathetic and parasympathetic cardiovascular modulation and baroreflex sensitivity in patients with osteoarthritis

Influence of non-surgical and surgical orthopedic treatment on stress and depression levels, sympathetic and parasympathetic cardiovascular modulation and baroreflex sensitivity in patients with osteoarthritis - Orthopaedic study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00004602

Enrollment

250

Registered

2012-12-14

Start date

2013-01-28

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M19 M17

Interventions

Group 1: Patients with osteoarthritis: examination of (I) sympathetic and parasympathetic cardiovascular activity and baroreflex sensitivity at rest and during standardized autonomic challenge maneuve

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 200 patients with osteoarthritis, 50 healthy adults

Exclusion criteria

Exclusion criteria: Patients with changes in any medications affecting autonomic regulation (e.g. antihypertensive drugs); patients with diabetes, cardiac arrhythmias, ischemic heart disease or chronic heart failure; patients with hallux rigidus, valgus deformity of the midfoot, other symptomatic deformity of the foot, advanced arthropathy of the hindfoot, previous joint arthrodesis, tibial osteotomy within the previous 5 years, knee joint lavage within the previous 3 months, intra-articular corticosteroid injection within the previous month, and changes in drug treatment for osteoarthritis within the previous week.

Design outcomes

Primary

Measure	Time frame
In patients with osteoarthritis, we will examine whether there are changes before, 1 month and 3 months after orthopaedic treatment (I) in sympathetic and parasympathetic cardiovascular activity and baroreflex sensitivity at rest and during standardized autonomic challenge maneuvers (active standing, Valsalva maneuver and metronomic deep breathing) (II) in pain intensity (visual analogue scales, „Western Ontario and McMaster Universities Osteoarthritis index“), course of pain (“German pain questionnaire“, „knee society knee score“), quality of pain, quality of life as well as stress level (“German pain questionnaire“, Likert scales) (III) in the level of depression (“Beck’s Depression Inventory”)	—

Measure

Time frame

In patients with osteoarthritis, we will examine whether there are changes before, 1 month and 3 months after orthopaedic treatment (I) in sympathetic and parasympathetic cardiovascular activity and baroreflex sensitivity at rest and during standardized autonomic challenge maneuvers (active standing, Valsalva maneuver and metronomic deep breathing) (II) in pain intensity (visual analogue scales, „Western Ontario and McMaster Universities Osteoarthritis index“), course of pain (“German pain questionnaire“, „knee society knee score“), quality of pain, quality of life as well as stress level (“German pain questionnaire“, Likert scales) (III) in the level of depression (“Beck’s Depression Inventory”)

—

Secondary

Measure	Time frame
For this study no secondary endpoints were defined.	—

Countries

Germany

Contacts

Public ContactJulia Köhn

Neurologische Universitätsklinik Erlangen

julia.koehn@uk-erlangen.de+49 9131 8544320

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026