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Incidence of delirium dependent on the type of sedation in ventilated ICU-patients - a prospective observationstudy with two patient cohhorts: midazolam/fentanyl vs. methohexital/fentanyl and propofol/remifentanil vs. methohexital/remifentanil

Incidence of delirium dependent on the type of sedation in ventilated ICU-patients - a prospective observationstudy with two patient cohhorts: midazolam/fentanyl vs. methohexital/fentanyl and propofol/remifentanil vs. methohexital/remifentanil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00004601
Enrollment
216
Registered
2013-01-03
Start date
2011-11-09
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F05.8 F05.9

Interventions

Group 1: Midazolam/Fentanyl vesus Methohexital/Fentanyl Group 2: Propofol/Remifentanil versus Methohexital/Remifentanil

Sponsors

Abt. f. Anästhesie und Perioperative Medizin, Asklepios Klinik Langen
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: All ventilated and sedated patients aged > 18 years

Exclusion criteria

Exclusion criteria: Aged < 18 years, known neurological or psychiatrical diseases, any diseases making communication impossible

Design outcomes

Primary

MeasureTime frame
VAS, RASS und ICDSC every 8 h during the stay on the ICU. Primary end point: ICDSC-points during ICU stay. Nullhypothesis: there is no significant difference in the incidence of delirium measured with the ICDSC between Midazolam/Fentanyl vs. Methohexital/Fentanyl and Propofol/Remifentanil vs. Methohexital/Remifentanil.—

Secondary

MeasureTime frame
Duration of mechanical ventilation, length of stay in ICU and hospital, mortality. Other variables: American Society of Anesthesiologists Classification (ASA), age, heigth, weight, sex, smoking status; SOFA, SAPS II, TISS 28 score; incidence of acute renal failure (RIFLE-criteria), numbers of interventions.—

Countries

Germany

Contacts

Public ContactHans-Bernd Hopf

Abt. f. Anästhesie und Perioperative Medizin, Asklepios Klinik Langen

h-b.hopf@asklepios.com061039121371

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026