Pharmacokinetics of Cefuroxim (CXM) and tranexamic acid (TXA) in children less than one year of age undergoing pediatric cardiac surgery.

Pharmacokinetics of Cefuroxim (CXM) and tranexamic acid (TXA) in children less than one year of age undergoing pediatric cardiac surgery. - TXA CXM Pharmacokinetics

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00004538

Enrollment

Registered

2013-01-04

Start date

2013-01-22

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

antibiotic concentrations (cefuroxime) antifibriniolytics (tranexamic acid) D68.9

Interventions

Group 1: Single arm, open, observational, non-randomized clinical trial to evaluate the perioperative pharmacokinetcis of cefuroxime and tranexamic acid with and without the use of cardiopulomonary by

Eligibility

Sex/Gender

All

Age

No minimum to 12 Months

Inclusion criteria

Inclusion criteria: Pediatric cardiac patients less than one year of age undergoing cardiac surgery with and without cardiopulmonary bypass.

Exclusion criteria

Exclusion criteria: Participation in any interventional study. Pretreatment with antibiotics and tranexamic acid.

Design outcomes

Primary

Measure	Time frame
Chromatographic determination of serum concentrations of cefuroxime and tranexamic acid with and without the use of cardiopulmonary bypass.	—

Secondary

Measure	Time frame
Determination of elimination half life, Clearance, AUC, maximaler Serumkonzentration Cmax and mean residence time (MRT) for both substances.	—

Countries

Germany

Contacts

Public ContactRalph Gertler

Klinikum Links der Weser

ralph.gertler@gmail.com0421-879-1731

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026