Quantitative Investigation of bioappearance and metabolism of trigonelline and its bioactive roasting products in coffee brew

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00004524

Enrollment

Registered

2013-03-12

Start date

2009-09-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy volunteers

Interventions

Group 1: coffee-group ( once only 350ml coffee) Group 2: control-group (once only 350ml water)

Eligibility

Sex/Gender

All

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: metabolically healthy volunteers

Exclusion criteria

Exclusion criteria: no consuming diseases

Design outcomes

Primary

Measure	Time frame
One of the aims is to collect quantitative plasma data on coffee constituents (in particular trigonelline and N-methylpyridinium) and metabolites of niacin by means of HPLC-MS/MS methods (stable isotope dilution assays), and analyse pharmacokinetic properties of the compounds. Measuring points are before and 15, 30, 45, 60, 120, 240, 360 und 480 min after coffee ingestion. First morning urine and urine is collected in a 2h time interval all day long.	—

Measure

Time frame

One of the aims is to collect quantitative plasma data on coffee constituents (in particular trigonelline and N-methylpyridinium) and metabolites of niacin by means of HPLC-MS/MS methods (stable isotope dilution assays), and analyse pharmacokinetic properties of the compounds. Measuring points are before and 15, 30, 45, 60, 120, 240, 360 und 480 min after coffee ingestion. First morning urine and urine is collected in a 2h time interval all day long.

—

Secondary

Measure	Time frame
Further, quantitation of carnitine, saturated acylcarnitine (C12 up to C18), and unsaturated acylcarnitine (C18:1, C18:2, C18:3) (Measuring points are before and 15, 30, 45, 60, 120, 240, 360 und 480 min after ingestion of coffee or water) shall give a hint as to whether coffee ingestion affects lipid metabolism.	—

Countries

Germany

Contacts

Public ContactYu-Mi Lee

Else Kröner-Fresenius-Zentrum für Ernährungsmedizin der TU München

ylee@wzw.tum.de08161-712007

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026