Optimized ventilation strategy in ARDS patients using transpulmonary pressures and volumetric capnography: an observational study

Optimized ventilation strategy in ARDS patients using transpulmonary pressures and volumetric capnography: an observational study - TPP Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00004436

Enrollment

Registered

2012-10-11

Start date

2012-05-08

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ARDS J80

Interventions

Group 1: Patients with ARDS: 3-4h study period using measurements of transpulmonary pressures and volumetric capnography during mechanical ventilation. Setting airway pressure based on published ARDSn

Eligibility

Sex/Gender

All

Age

18 Years to 120 Years

Inclusion criteria

Inclusion criteria: ARDS P/F ratio less than 300 mechanically ventilated

Exclusion criteria

Exclusion criteria: lack of consent, severe preexisting lung disease, ECMO therapy , PECLA therapy

Design outcomes

Primary

Measure	Time frame
Oxygenation: measuring paO2 every 20 min after each new PEEP level, measured by blood gas analysis Dead space ventilation: measured in ml, every 20 mins using volumetric capnography	—

Secondary

Measure	Time frame
Airway pressures every 20 min, measured by ventilator transpulmonary pressures every 20 min, measured by esophageal pressure monitor	—

Countries

Germany

Contacts

Public ContactOnnen Mörer

ZARI , UMG Göttingen

omoerer@med.uni-goettingen.de0551 399561

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026