Time-course of CNS cytokine concentrations after elective orthopedic procedures in the elderly and their possible role as biomarkers for delirium

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00004413

Enrollment

Registered

2012-10-04

Start date

2012-06-10

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F05.0 F05.1

Interventions

Group 1: Patients with elective major orthopedic surgery (hip replacement)

preoperatively: Mini Mental Status Test (MMMST), Confusion Assessment Method (CAM). Postoperatively: CAM (twice a day). At all three times CSF and blood samples.

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: elective major orthopedic surgery (hip replacement); normal preoperative scores in MMST; normal preoperative scores in CAM

Exclusion criteria

Exclusion criteria: non-elective surgery; MMST or IQCODE or CAM indicating cognitive impairment or preexisting delirium

Design outcomes

Primary

Measure	Time frame
Time-course of cytokine concentrations in CSF and blood (before surgery and on first and second day post OP)	—

Secondary

Measure	Time frame
Delirium; further postoperative complications; death; lung emboly; pain; heart failure; apoplexia. Routine examinations of blood, visual analogue scale (VAS - twice a day - pain) and Confusion Assessment Method (CAM - twice a day - delirium)	—

Countries

Germany

Contacts

Public ContactSimone Gurlit

St. Franziskus-Hospital Münster Klinik für Anästhesie und operative Intensivmediizin

simone.gurlit@sfh-muenster.de+49-251-9353936

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026