Effects of early, combined endurance and resistance training on mechanically ventilated, critically ill patients – a randomised controlled trial

Conditions

Intensive Care Unit Aquired Weakness G62.80 G72.80

Sabrina Eggmann, Irina Irincheeva, Gere Luder, Martin L. Verra, André Moser et al. (7 authors)

PLoS ONE2022-02-0312 citations

10.1371/journal.pone.0262779

Functional ability and quality of life in critical illness survivors with intensive care unit acquired weakness: A secondary analysis of a randomised controlled trial

Sabrina Eggmann, Gere Luder, Martin L. Verra, Irina Irincheeva, Caroline H. G. Bastiaenen et al. (6 authors)

PLoS ONE2020-03-0467 citations

10.1371/journal.pone.0229725

Effects of early, combined endurance and resistance training in mechanically ventilated, critically ill patients: A randomised controlled trial

Sabrina Eggmann, Martin L. Verra, Gere Luder, Jukka Takala, Stephan M. Jakob

PLoS ONE2018-11-14122 citations

10.1371/journal.pone.0207428

Effects of early, combined endurance and resistance training in mechanically ventilated, critically ill patients: a study protocol for a randomised controlled trial

Sabrina Eggmann, Martin L. Verra, Gere Luder, Jukka Takala, Stephan M. Jakob

Trials2016-08-1519 citations

10.1186/s13063-016-1533-8

Interventions

Group 1: Control group: usual physiotherapy care, such as range of motion therapy, mobilisation and activities of daily living Group 2: Intervention group: passive / active training with a bedside cyc

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: =18 years expected mechanical ventilation for >72 hours on a interdisciplinary intensive care unit qualitatively independent before illness

Exclusion criteria

Exclusion criteria: contraindication for bedside ergometer MOTOmed weight > 150kg preexisting neuromuscular / neurological disease with enduring functional limitations former hospital stay of more than 10 days limited therapy because of expected poor outcome inclusion in other intervention study admission diagnosis that makes a walking test at hospital discharge impossible

Design outcomes

Primary

Measure	Time frame
The functional exercise capacity using the 6 Minute Walking Test The independence during activities of daily living measured with the Functional Independence Measure. Both assessments are evaluated at the time of hospital discharge.	—

Secondary

Measure	Time frame
Muscle Force (precondition: patient follows 3 of 5 commands) - Medical Research Council sum score (MRC) for 6 muscle groups - handgrip force using the JAMAR Dynamometer - quantitiv muscle force of the Quadriceps using a Hand Held Dynamometer Tests from day 7 (follow-up every 14 days) and at ICU discharge. Joint mobility, Range of motion using a Goniometer and the Neutral-0-Method. Tests from day 7 and at ICU discharge. Functional exercise capacity using the Timed-Up-And-Go Test at hospital discharge. Length of stay in the ICU and hospital, achieved milestones during the ICU. Quality of live, using the Short Form36, 6 months after hospital discharge.	—

Measure

Time frame

Muscle Force (precondition: patient follows 3 of 5 commands) - Medical Research Council sum score (MRC) for 6 muscle groups - handgrip force using the JAMAR Dynamometer - quantitiv muscle force of the Quadriceps using a Hand Held Dynamometer Tests from day 7 (follow-up every 14 days) and at ICU discharge. Joint mobility, Range of motion using a Goniometer and the Neutral-0-Method. Tests from day 7 and at ICU discharge. Functional exercise capacity using the Timed-Up-And-Go Test at hospital discharge. Length of stay in the ICU and hospital, achieved milestones during the ICU. Quality of live, using the Short Form36, 6 months after hospital discharge.

—

Countries

Switzerland

Contacts

Public ContactStephan Jakob

Universitätsklinik für Intensivmedizin Inselspital, Universitätsspital Bern

stephan.jakob@insel.ch+41 632 11 76

Outcome results

None listed