J96
Conditions
Interventions
Group 1: ATC mode is off initially, when the measurements start. Then the ATC mode is turned on for 10 minutes, then turned off for 10 minutes and again the ATC mode is on for 10 minutes. The measurem
Sponsors
Paediatrische und neonatologische Intensivstationen, Zentrum fuer Kinder- und Jugendmedizin, Universitaetsklinik Freiburg
Eligibility
Sex/Gender
All
Age
1 Months to 12 Years
Inclusion criteria
Inclusion criteria: aged 4 weeks - 12 years, endotracheal tube 3,5-6,5, invasive BIPAP-ventilation per EVITA with Fi02 < 40%, spontaneous ventilation of 60 %.
Exclusion criteria
Exclusion criteria: severe lung pathology, Fi02 > 40%, large tube leak, < 60% spontaneous ventilation, cardiovascular failure (more than 5 µg/kg/min dopamine), neurological disease (e.g. epilepsy, cerebral edema), necessity for neuromuscular blockade or deep analgosedation leading to <60 % of spontaneous ventilation, severe hepatic or kidney failure, missing parental consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| With the ATC-mode switched on, we expect a reduction of work of breathing. The primary endpoint is the work of breathing. The pressure flow is measured and subsequently the work of breathing is calculated offline. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoints are Fi02, C02, oxygen-saturation, respiratory rate, heart rate, blood pressure. We expect the parameters of oxygenation and ventilation (Fi02-reduction, C02-decrease, improvement of saturation, clinical reduction in the patients' effort of breathing, e.g. reduction of respiratory rate) to improve, as well as stress reduction (normocardia, normotonia) when the ATC-mode is switched on. | — |
Countries
Germany
Contacts
Public ContactRuth Creutzfeldt
Paediatrische und neonatologische Intensivstationen, Zentrum fuer Kinder- und Jugendmedizin, Universitaetsklinik Freiburg
Outcome results
None listed