Stress, Obesity, Liver fat, Insulin resistance in Depression

Stress, Obesity, Liver fat, Insulin resistance in Depression - SOLID

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00004324

Enrollment

Registered

2012-08-21

Start date

2008-06-23

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F32 F33

Interventions

Group 1: healthy controls: psychiatric and medical history, physical examination, laboratory analyses of blood, ECG in order to test exclusion criteria. Functional imaging of the brain (MRI), breast a

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients: depressive episode (unipolar), severity: HDRS >= 18

Exclusion criteria

Exclusion criteria: Patients and controls: not competent for consent, insufficient german language, diabetes, dyslipidemia, contraindication for MRI

Design outcomes

Primary

Measure	Time frame
This is a non-interventional trial. The above-mentioned dependent variables will be compared between healthy controls and depressed patients as well as between subgroups of depressed patients (e.g. high vs. low activity of the HPA system): functional imaging of the brain (MRI), breast and abdominal imaging (MRI), blood analysis for metabolic and genetic parameters, dexamethasone suppression test, cortisol in saliva and urine. This is a cross-sectional trial.	—

Measure

Time frame

This is a non-interventional trial. The above-mentioned dependent variables will be compared between healthy controls and depressed patients as well as between subgroups of depressed patients (e.g. high vs. low activity of the HPA system): functional imaging of the brain (MRI), breast and abdominal imaging (MRI), blood analysis for metabolic and genetic parameters, dexamethasone suppression test, cortisol in saliva and urine. This is a cross-sectional trial.

—

Countries

Germany

Contacts

Public ContactMichael Deuschle

Zentralinstitut für Seelische Gesundheit

michael.deuschle@zi-mannheim.de0621 1703 2331

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026