Effect of hypoxia on diaphragmatic strength during isolated exercise of respiratory muscles

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00004323

Enrollment

Registered

2012-09-04

Start date

2012-09-06

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy participants

Interventions

Group 1: (hypoxia) Before the inspiratory muscle loading, subjects diaphragmatic contractility is assessed by using twich transdiaphragmatic pressure during magnetic phrenic nerve stimulation (TwPdi),

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: healthy subjects older than 18years

Exclusion criteria

Exclusion criteria: pregnancy, metal implantsof any kind, lung-, heart-, or neuromuscular disease, thorax deformities or pneumothorax in the past

Design outcomes

Primary

Measure	Time frame
Progression of diaphramatic contractility during inspiratory muscle training in hypoxia and normoxia. Using twich transdiaphragmatic pressure after magnetic phrenic nerve stimulation (TwPdi) measured every 45s.	—

Secondary

Measure	Time frame
Decrease of diapragmatic contractility after inspiratory muscle training in hypoxia compared to normoxia. Using twich transdiaphragmatic pressure after magnetic phrenic nerve stimulation (TwPdi) assessed every 60s for 6min.	—

Countries

Germany

Contacts

Public ContactDavid Walker

Abteilung Pneumologie Universitätsklinik Freiburg

david.walker@uniklinik-freiburg.de0761 270 37060

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026