metabolism of resveratrol in healthy volunteers
Conditions
Interventions
Group 1: Vineatrol, 0,5 mg resveratrol-equivalents per kg body weight (single oral dose as gelatine capsule)
Group 2: resverasorb, 0,5 mg resveratrol-equivalents per kg body weight (single oral dose a
Sponsors
Max Rubner-Institut
Eligibility
Sex/Gender
Male
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: healthy men (18 - 40 Jahre) BMI 20 – 25 kg/m2 non-smoker participants, who gave written informed consent
Exclusion criteria
Exclusion criteria: Subjects with serious diseases related to nutrient absorption, digestion, metabolism and excretion. Subjects who used nutritional supplements or medication within the last three months which might interact with parameters of interest. Subjects that might be non-compliant. Subjects with allergies on the study substance or other ingreedients of the formulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC, Camx, tmax of resveratrol and its metabolites in plasma. Analysis by LC-MS/MS before, 20, 40, 60, 90, 120, 180, 270, 360, 480, 720 min and 24h after intake. | — |
Secondary
| Measure | Time frame |
|---|---|
| Resveratrol and metabolite excretion in urine. Analysis by LC-MS/MS of sample periods 0-4h, 4-8h, 8-12h, and 12-24h. | — |
Countries
Germany
Contacts
Public ContactAnita Kriebel
Max Rubner-Institut
Outcome results
None listed