F20.0
Conditions
Interventions
Group 1: Patients
All subjects are screened for possible exclusion criteria. Subjects that gave their informed consent will undergo neuropsychological testing. The investigated domains include attenti
Sponsors
Zentralinstitut für Seelische Gesundheit
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: All subjects: • Adequate proficiency in German language • Ability to understand the study protocol and give informed consent For patients: • Subjects have to meet DSM-IV criteria for schizophrenia • Stable monotherapy or unmedicated patients, infrequent use of benzodiazepines is allowed (last use >24 hours before study to avoid influence on cognitive functions)
Exclusion criteria
Exclusion criteria: • subjects with a psychiatric condition (healthy controls), acute worsening of symptoms or additional psychiatric condition (patients) • presentation with a severe neurological disorder • major medical conditions e.g. renal failure, hepatic cirrhosis • pregnancy • metal implants • tatoos covering head or neck • claustrophobia • substance abuse (excluding nicotine and caffeine) • arterial hypertension • diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| •Characterization of task-related BOLD activation in healthy subjects and patients using both univariate (statistical parametric mapping) and multivariate methods („machine learning“). •Evaluation of prefrontal-hippocampal connectivity during working memory processes. •Modulation of both activity and connectivity patterns by psychiatric risk polymorphisms. | — |
Secondary
| Measure | Time frame |
|---|---|
| • Comparison of imaging data with biophysical models (cooperation with Prof. Dr. Daniel Durstewitz) to gain a better mechanistic understanding of underlying (patho)physiological processes • Development of multivariate statistical methods that can be used with functional imaging data • Correlation of neuropsychological and imaging data | — |
Countries
Germany
Contacts
Public ContactPeter Kirsch
Zentralinstitut für Seelische Gesundheit
Outcome results
None listed