Imaging of plasticity in circuits of the forebrain: biomarkers, pathophysiology, and genetic mechanisms

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00004255

Enrollment

190

Registered

2012-07-27

Start date

2011-06-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F20

Interventions

Group 1: Arm 1: Cross-sectional design, healthy controls a) Acquisition of cognitive and personality variables for sample characteristics b) Blood withdrawal for genetic analyses c) Acquisition of fun

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Right-handedness, German natives - Ability to understand and accept study protocol - For patients: Diagnosis of schizophrenia (DSM-IV criteria) - For Relatives: Validated diagnosis by medical staff

Exclusion criteria

Exclusion criteria: - MRI-exclusion criteria (metal parts in body, brain operations, permanent make-up) - Migration background - Psychiatric diagnosis in controls and relatives

Design outcomes

Primary

Measure	Time frame
a) Acquisition of data b) Identifikation of biomarkers and their (genetic) modulation c) Identifikation of defizits in those biomarkers in schizophrenic patients	—

Secondary

Measure	Time frame
Development of new strategies to analyze data	—

Countries

Germany

Contacts

Public ContactHeike Tost

Zentralinstitut für Seelische Gesundheit

heike.tost@zi-mannheim.de0621 1703-6510

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026