Plasticity in prefrontal cortical regions in humans: genetic variation, cellular mechanisms and modulation by means of neurofeedback

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00004252

Enrollment

100

Registered

2012-08-02

Start date

2012-02-16

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

haelthy subjects

Interventions

Group 1: Arm 1: Repetitive transcranial magnetic stimulation (rTMS) in healthy controls Plasticity induction in prefrontal brain regions by means of rTMS. Modulation of plasticity by genetic risk vari

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: - right handedness, german native speaker - ability to understand study protocol and give written informed consent

Exclusion criteria

Exclusion criteria: - MR exclusion criteria (metal implants, brain surgery, permanent makeup) - Migration background - History of epilepsy or psychiatric disorders (also in first grade relatives).

Design outcomes

Primary

Measure	Time frame
Find evidence for genetic influence on rTMS induced cortical plasticity and it’s relation to cellular parameters. Activity and connectivity markers obtained from fMRI during working memory, rest, and behavioral inhibition will serve as indicators.	—

Secondary

Measure	Time frame
Establishment of realtime connectivity neurofeedback as well as the necessary training paradigm.	—

Countries

Germany

Contacts

Public ContactAxel Schäfer

Zentralinstitut für Seelische Gesundheit

axel.schaefer at zi-mannheim.de0621 1703 6523

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026