Impact of different positive end-expiratory pressure (PEEP) with low tidal volumes during one-ventilation on lung mechanics, gas exchange, and hemodynamics

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00004247

Enrollment

276

Registered

2012-07-24

Start date

2012-08-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Onel-lung ventilation

Interventions

Group 1: Lung recruitment before one-lung ventilation / PEEP 5 Group 2: Lung recruitment before one-lung ventilation / PEEP 8 Group 3: No lung recruitment before one-lung ventilation / PEEP 5 Group 4:

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Thoracic Surgery Onelung ventilation

Exclusion criteria

Exclusion criteria: Lack of informed consent Incapability to give informed consent Severe impairment of pulmonary function (<75%) Previous partial lung resection

Design outcomes

Primary

Measure	Time frame
Oxygenation after 30 min one-lung ventilation measured by arterial pO2 in the blood gas analysis	—

Secondary

Measure	Time frame
Dynamic compliance during one-lung ventilation calculated from the parameters of mechanical ventilation, Ventilation during one-lung ventilation measured by arterial pCO2 in the blood gas analysis, Frequency of clinically significant hypoxemia (necessity to apply CPAP or two-lung ventilation)	—

Countries

Germany

Contacts

Public ContactWahedulla Karzai

Zentralklinik Bad Berka Klinik für Anästhesie und Intensivemdizin

karzai@zentralklinik.de+49 (0)36458 5-1001

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026