R06.0
Conditions
Interventions
Group 1: Palliative care patients with dyspnoea receiving opioid-PCA therapy, assessment of the severity of dyspnea with a numeric rating scale from 0 to 10 (NRS 0 = no dyspnea, NRS 10 = maximal ima
documentation of physiological parameters, of side effects and PCA data at specified points in time.
Sponsors
Interdisziplinäres Zentrum für Palliativmedizin
Universitätsklinikum Düsseldorf
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Dyspnea >/= NRS 3; inpatients of the University Hospital Dusseldorf, who are treated by the Interdisciplinary Center for Palliative Medicine; indication for PCA therapy in the context of standard treatment of dyspnea; cognitive, physical and verbal skills, that allow the correct handling of a PCA pump
Exclusion criteria
Exclusion criteria: cognitive, physical and/or linguistic limitation that does not allow the correct handling of an PCA pump; Minimal-Mental State Examination (MMSE) <24 (of 30 max.); allergy, known intolerance or contraindications to morphine and hydromorphone; pregnancy; taking monoamine oxidase inhibitors (MAOI) in the last 2 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of dyspnea under opioid PCA therapy, on a numeric rating scale from 0 to 10 (NRS 0 = no breathlessness, NRS 10 = maximal imaginable breathlessness) severity is measured before the start of PCA therapy, 5 minutes, 15 minutes, 60-120 minutes, 1 day after initiation of therapy and at each subsequent day of therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in physiological parameters measured as respiratory rate, oxygen saturation and Palliative Performance Scale (PPS) before the start of PCA therapy, 5 minutes, 15 minutes, 60-120 minutes, 1 day after initiation of therapy and at each subsequent day of therapy; the measuring of satisfaction and acceptance of the therapy using a 6-question questionnaire, 24 and 72 hours after initiation of therapy; description of adverse reactions under PCA opioid therapy before the start of PCA therapy, 5 minutes, 15 minutes, 60-120 minutes, 1 day after initiation of therapy and at each subsequent day of therapy; application profile (opioids and their doses, PCA parameters: bolus dose, basal rate, locking time, number and size of boluses given by physicians, number of required and administered boluses by the patient, total dose) before the start of PCA therapy, 5 minutes, 15 minutes, 60-120 minutes, 1 day after initiation of therapy and at each subsequent day of therapy | — |
Countries
Germany
Contacts
Public ContactAndrea Schmitz
Interdisziplinäres Zentrum für Palliativmedizin Universitätsklinikum Düsseldorf
Outcome results
None listed