TYP-2-DIABETES E11.9
Conditions
Interventions
Group 1: All family members: physical investigation, body composition (bioimpedance analysis), fasting blood sampling, spontaneous Urine sample, faecal samples (optional), dietary record, physical act
Sponsors
Else Kröner-fresenius-Zentrum für Ernährungsmedizin
Klinikum rechts der Isar der TU München
Uptown München Campus D
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: - type 2 diabetes families: at least two generations (parents, children); at least one parent with T2D; at least three participants per family (“trio”) with one disease-free index subject - Caucasian origin - no BMI restriction - written informed consent
Exclusion criteria
Exclusion criteria: - severe diseases, e.g. cancer, COPD, severe heart disease, progressive renal failure, severe psychiatric or neurological diseases - type 1 diabetes, MODY or other rare types of diabetes - drug or alcohol abuse - continuous treatment with drugs influencing glucose tolerance, insulin sensitivity and/or insulin secretion - continuous treatment with oral anticoagulants or antithrombotics (except ASS 100) - gastrointestinal diseases impairing glucose absorption during oGTT - insufficient language skills - lack of written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Characterization (geno-/phenotyping) of a cohort of families with type 2 diabetes. | — |
Secondary
| Measure | Time frame |
|---|---|
| - identification of potential new diagnostic biomarkers in a T2D risk cohort - validation and cross-validation of newly detected biomarker signatures - function of diabetes-related single nucleotid polymorphisms - development and validation of specific dietary recommendations for disease prevention | — |
Countries
Germany
Outcome results
None listed