E66.9
Conditions
Interventions
Group 1: mechanical ventilation by means of individualized positive end-expiratory airway pressure (PEEP)
Group 2: standard mechanical ventilation
Sponsors
Klinik und Poliklinik für Anästhesiologie und
Intensivtherapie
Universitätsklinikum Leipzig
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Age >= 18 years - obesity grpup: BMI = 35 kg/m² - group with normal weight: BMI = 18,5 to 25 kg/m² - need for surgery with intermediate or high risk for post–operative pulmonary complications (ARISCAT score higher than or equal to 26) - informed consent
Exclusion criteria
Exclusion criteria: - Need for neurosurgery, cardiothoracic, head, neck and liver surgery - Persistent hemodynamic instability - History of previous severe chronic obstructive pulmonary disease (COPD) or acute lung injury - Pregnancy (excluded by laboratory analysis) - severe cardiac disease (NYHA III or IV, or acute coronary syndrome, or persistent ventricular tachyarrhythmias) - Neuromuscular disease of all types - Surgery longer than 30 minutes within last 30 days of all types - cardiac peacemaker or other implanted stimulation devices
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative oxygenation, measured by ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2) directly before extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| - oxygenation at different times - End-expiratory lung volume (EELV) - post–operative pulmonary and extra–pulmonary organ failure (SOFA) - days in intensive care unit and hospital | — |
Countries
Germany
Contacts
Public ContactPhilipp Simon
Klinik und Poliklinik für Anästhesiologie und Intensivtherapie Universitätsklinikum Leipzig
Outcome results
None listed